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When HK-2 cells were treated with MLN4924, the UBE2m overexpression-induced increase in neddylation and expression of NEDD4 was rescued, as was the decrease in PPAR expression induced by NEDD4 elevation (Fig

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10.1007/s00018-014-1764-3 Cell

However, as accessibility increases, the conversation around medical supervision and responsible use must become louder than ever