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However, recent studies have found that there is no increased risk of complications in those whose IVs were replaced only when clinically indicated versus those whose IVs were replaced routinely

Finally, the metastable sets were computed using the PCCA+ spectral clustering implemented in pyEMMA

The dedicated cardiovascular trial did not find excess major events and reported lower all-cause mortality, but resting heart rate remains a titration marker rather than a one-time measurement. How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but escalation speed is the largest modifiable driver of side effects

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Weeks 5 to 8 (dose escalation to 0.6 mg) Nausea becomes more noticeable in some individuals as the dose doubles

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