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This is because the skin is often the last organ to receive nutrients

SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103

Elevated GH and IGF-1 are associated with improved fat metabolism, lean muscle preservation, and better body composition

The effect of preoperative melatonin on nuclear erythroid 2-related factor 2 activation in patients undergoing coronary artery bypass grafting surgery

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