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[1] Current clinical treatment options include urate-lowering agents such as allopurinol and febuxostat, as well as anti-inflammatory drugs such as colchicine for acute gout flares

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It also has a profound effect on wound healing and tissue damage, commonly caused by corticosteroid use

Two additional enzymes of folate metabolism, aldehyde dehydrogenase 1 family member L1 (encoded by the ALDH1L1 gene) and ALDH1L2, produce NADPH in the course of converting N 10 -formyltetrahydrofolate (10-formyl-THF) to tetrahydrofolate (THF) and CO 2

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