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Overall these results confirm that FOXO4-DRI promotes apoptosis in senescent endothelial cells by inhibiting FOXO4-P53 binding and phosphorylating P53

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Complementing the EAE model, an additional demyelination model -induced by cuprizone diet- was employed to further confirm that the remyelination effect of T4 derives from its direct action on OPCs

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With prolonged agonist treatment, relative preservation of surface GLP-1Rs was detected with exendin-phe1 (Fig

2014;9(5):e97554