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doi: 10.1016/0140-6736(93)90754-5

75,76 Although other sources of oxidants (H 2 O 2 ) than the electron transport chain have been identified in relation to fatty acid metabolism within mitochondria, 77,78 the formation of peroxynitrite as the critical oxidant for mitochondrial dysfunction requires superoxide, which is generated by the electron transport chain

Despite the heterogeneity of this group of diseases, mitochondria seem to be a pivotal crossroads in the biological processes promoting neurodegeneration as well as predicting clinical outcomes [10, 108]

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Environmental factors such as cold weather, low humidity, harsh soaps, and frequent washing can exacerbate dryness