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Headaches are a recognized adverse effect of GLP-1 receptor agonist therapy, though they vary in frequency across different medications, doses, and patient populations

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[1] The medication works through dual agonism of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, which helps regulate appetite and reduce food intake

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In the control (placebo) group, side effects occurred in 18% of participants receiving metformin and 19.2% without metformin

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