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Ferroptosis is one of the novel mechanisms of anesthesia-induced neurotoxicity in developing brain Ferroptosis is another novel kind of programmed cell death characterized by iron-dependent lipid peroxides accumulation ( Meanwhile, exposure to sevoflurane might also lead to iron-induced neurotoxicity in the hippocampus and cognitive dysfunction by upregulating NMDA receptors and enhancing divalent metal transporter 1 (DMT1)-mediated iron upregulation and iron release from lysosome ( Clinical concentration might lead to dysregulation of gut microbiota The dysregulation of the gut microbiota might also influence the immature brain

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