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Please seek a healthcare professionals advice to understand which treatments are suitable

To form SAG, His 18 deprotonates SA hydroxyl, and thus must be deprotonated before the reaction begins

September 22, 2023

(M/F) 21/25 21/24 20/23 20/23 20/22 Weight (Kg) 94.5 9.6 92.7 9.4 90.3 8.4 88.1 7.2* 85.0 5.9** BMI (Kg/m2) 33.1 2.9 32.5 2.3 31.6 1.8 30.8 1.5* 29.8 1.2** HbA1c (%) 8.4 1.4 8.1 1.2 7.7 0.9* 7.3 0.6** 7.0 0.5^ FPG (mg/dL) 136 16 132 14 129 13 126 12 121 11* PPG (mg/dL) 174 24 170 19 163 17 156 16* 149 13** FPI (U/mL) 22.8 5.7 22.1 5.2 21.3 4.7 20.2 4.5* 19.3 4.2$ HOMA- IR 7.7 4.2 7.0 3.6 6.6 3.4 6.1 3.2* 5.6 2.8$ TC (mg/dL) 220 24 212 17 207 15 194 11* 186 9$ LDL-C (mg/dL) 153 15 149 11 144 8 134 7* 126 6$ HDL-C (mg/dL) 45 7 44 6 46 8 45 7 46 8 Tg (mg/dL) 109 48 95 39 84 30 76 27 72 25* Resistin (ng/mL) 6.9 2.5 6.1 2.1 5.7 1.7 5.3 1.5* 5.0 1.2$ RBP-4 (g/mL) 42.1 10.2 40.3 9.9 37.1 8.6 35.8 8.3 33.6 7.2* Visfatin (ng/mL) 17.8 6.4 16.9 5.9 16.4 5.4 16.1 5.5 15.7 5.1* Hs-CRP (mg/L) 2.5 1.6 2.3 1.4 1.9 1.1 1.7 0.9* 1.5 0.6$ Data are means SD

Possible biases caused by the randomization process, deviations from intended interventions, missing data, outcome measurements, and selective reporting were rated as high risk, low risk, or some concerns

5 however, L-carnitine has been shown in several studies to improve liver function in NASH patients and prevent the progression of the disease