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Human thyroid cancer cell lines Human PTC cell lines K1 and TPC-1 (Sigma-Aldrich, St

puf-8(/) germline tumors are derived from the failure of meiotic entry in the distal mitotic cells as seen in gld-2(/) gld-1(/) germline tumors, and (2) conversely, gld-2( +/ ) gld-1( +/ )

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Thus, an overactive neuroinflammatory response of astrocytes and microglia can contribute to BD development by alterations in immune response that leads to an increase in not only BBB integrity but also in intestinal permeability [147]

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Providers should monitor weight trajectory , GI tolerability (nausea, vomiting, constipation) , signs of pancreatitis (persistent severe abdominal pain vomiting), gallbladder disease (RUQ pain, fever, jaundice), hydration/renal function when clinically indicated (risk of AKI with severe GI effects), blood pressure , and glucose metrics (especially if combined with insulin or sulfonylureas due to hypoglycemia risk)