In the pancreas, it improves insulin production and lowers glucagon, a hormone that raises blood sugar
But if you are sensitive to side effects, currently in the dose-escalation phase, or already experiencing tirzepatide fatigue or GI symptoms, the extra residual drug could amplify those effects temporarily
The right choice hinges on your starting weight, your other conditions, your insurance, what side effects you can tolerate, and what you actually want out of treatment
Surprisingly, the SURMOUNT-5 trial found that fewer people discontinued tirzepatide due to side effects (2.7%) compared to semaglutide (5.6%)
and limiting caffeine can significantly reduce symptoms
That meant compounders would be acting illegally if they compounded tirzepatide, the main ingredient in Zepbound and Mounjaro