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The successful development of glucagon-like peptide-1 (GLP-1) receptor agonists, followed by the synergistic combined effect of glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists achieved remarkable weight loss and glycemic control in those with the diseases of obesity and type 2 diabetes

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Next, water molecules and small molecule ligands were removed from the protein, hydrogen was added, and the active pockets in the 3D structure of the protein were identified by AutoDock Tools

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These versions may contain contaminants, synthetic dyes, or inconsistent dosing, and they typically lack quality control or clinical oversight