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The primary metabolite M1 had a short half-life (approximately 3 hours) whereas the secondary metabolite M3 eliminated at a slower rate (half-life approximately 13.5 hours)

cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha

Increased fluid intake may be needed if experiencing nausea, vomiting, or diarrhea, as dehydration frequently underlies headaches in patients taking these medications

[DOI] [PubMed] [Google Scholar] 37.Maioli S., Leander K., Nilsson P., Nalvarte I

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