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(doi:10.1007/s00125-010-1937-z) report that metformin acutely increases plasma levels of glucagon-like peptide 1 (GLP-1) in mice

Together, these results demonstrated that PI3K/Akt signaling was involved in the protective effect of GLP-1R

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It is crucial to consult with a healthcare provider who can conduct a comprehensive assessment of your specific health profile, weight loss objectives, and other relevant considerations