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PMID: 37062921

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19 Safety Profile and Regulatory Status Allulose has received Generally Recognized as Safe (GRAS) designation from the U.S

The proposed direct vascular mechanisms, supported by preclinical and clinical data, include the following: Endothelial protection: GLP-1 receptor agonists promote nitric oxide production, vasodilation, and angiogenesis while inhibiting oxidative stress in vascular endothelial cells Plaque stabilization: Reduced matrix metalloproteinase activity prevents fibrous cap degradation

Am J Clin Dermatol 12:8799 Vera-Sirera B, Risueo-Mata P, Ricart-Vaya JM et al (2012) Clinicopathological and immunohistochemical study of oral amalgam pigmentation