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Downstream marker assays can include phosphoprotein panels, transcript level response mapping, and functional proxy assays that explore changes in cellular state under controlled exposure logic

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Combination therapies: multimodal strategies to overcome drug resistance CRC is characterized by high metabolic plasticity, which often undermines the durability of single-target therapies

Inside tumors, lymphatic vessels are compressed (68, 81), possibly due to the solid stress exerted by growing cancer cells (32, 44, 45, 55, 56, 68, 8286), but functional lymphatic vessels in the tumor periphery remain and can transport antigen and metastatic cancer cells

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