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Melasma Oxidative stress that occurs in melanocytes also significantly contributes to the development of melasma, a skin disorder characterized by hyperpigmentation on sun-exposed areas of the skin 123

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Additionally, there was a significant decrease in renalase activity and urine osmolality, alongside a significant increase in IL-1, IL-6, and TNF- levels and a decrease in IL-10 levels

Risk factor such as alcohol abuse, high cholesterol diets, and prolonged fasting denature bile salt loss or modify gut microbiota, intensifying enterohepatic bilirubin recycling [10, 38]

Degraded peptide retains appearance but loses potency

Acknowledgements The authors would like to thank all study participants who contributed their time to this project