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The inactivation or silencing of Gpx4 gene expression can result in the death of the embryo, possibly due to developmental defects in the brain ( GPX4 are associated with sedaghatnia-type spondylometaphyseal chondrodysplasia, which causes bone, heart, and brain abnormalities and increased cell death (Smith et al., 2014)

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As a consequence, cells of the liver, adipose tissue, adrenal cortex, testis, and lactating mammary gland have high levels of the PPP enzymes

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Digestive Disorders: Individuals with conditions such as Crohns disease or celiac disease may experience impaired absorption of B12 in the intestines