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This reflects a cost-containment decision by Kaiser CA and Blue Shield of California applied an identical BMI-40 restriction at the same time
Brettschneider J, Lehmensiek V, Mogel H, Pfeifle M, Dorst J, Hendrich C, Ludolph AC, Tumani H
| Parameter | Orforglipron (oral pill) | Retatrutide (injectable peptide) | | --- | --- | --- | | Molecular class | Non-peptide small molecule | Peptide (amino acid chain) | | Receptor profile | GLP-1 (single target) | GIP + GLP-1 + glucagon (triple) | | Administration | Oral, tablet | Subcutaneous injection | | Interval | Once daily | Once weekly | | Half-life | Short (daily dosing) | approx
Aim for at least 8-10 glasses of water per day, and consider adding electrolyte-rich beverages like coconut water or sports drinks to help replenish lost electrolytes
10.1177/03635465251323001 87 SkinnerS
Higher Fat Utilization Your body becomes better at using fatbut results depend on overall energy balance
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