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For VPA targets, the top 3 hub proteins based on degree were Prostaglandin-Endoperoxide Synthase 2 (PTGS2/COX2), Mammalian Target of Rapamycin (mTOR), and Toll Like Receptor 4 (TLR4), while the top 3 hub proteins based on BC score were PTGS2, mTOR, and Cannabinoid Receptor 1 (CNR1)

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However, that debate was extinguished in a landmark 2015 publication in the European Journal of Nutrition

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This dysfunction compromises cellular energy metabolism, increases oxidative stress, and triggers apoptotic cascades