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Mechanistically coupled PK (MCPK) model to describe enzyme induction and occupancy dependent DDI of dabrafenib metabolism
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Inflammation causes tryptophan to be reallocated from serotonin synthesis to that of kynurenine, which then converts to the neurotoxin quinolinic acid, leading to depression
Scand J Gastroenterol 2018
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Nature 404 , 635643 (2000)
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