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Published clinical trials used continuous daily administration for 12-24 weeks without scheduled breaks, establishing this as a viable approach with maintained safety throughout the treatment period

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The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

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doi:10.1016/j.regpep.2009.11.012 26

10.1016/j.amsu.2021.102793 [DOI] [PMC free article] [PubMed] [Google Scholar] Feng G.-K., Liu R.-B., Zhang M.-Q., Ye X.-X., Zhong Q., Xia Y.-F., et al