Stay socially connected Social support, emotional closeness, and meaningful connections help buffer stress responses and reduce hypothalamic-pituitary-adrenal (HPA) axis activation - the system that regulates cortisol release
With continued immune modulation over time.*
(1997) Expression of adrenocorticotrophic hormone receptor mRNA in human adrenocortical neoplasms: correlation with P450scc expression
Conservative research protocols stay at or below 50 mcg/day
These effects are attributed to their content of key growth factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF), and transforming growth factor beta (TGF-) [28] all of which are known to influence angiogenesis, cell survival, stem cell proliferation, and tissue remodeling [29,30,31]
These IGF-1 axis studies have established Ipamorelin as the reference GHS-R1a agonist for studying GH-driven IGF-1 biology in research protocols where prolactins independent IGF-1-stimulating biology in liver and peripheral tissues would otherwise confound interpretation
