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In mitochondria, DHODH can reduce CoQ to ubiquinol (CoQH2), reducing oxygen free radicals, inhibiting the generation of phospholipid hydroperoxide (PLOOH), and inhibiting phospholipid peroxidation, thereby inhibiting ferroptosis

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doi: 10.3390/nu14163265 [DOI] [PMC free article] [PubMed] [Google Scholar] 173

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Verification with another isogenic PSC pair To confirm that the increased A secretion and the inhibitory effect of high-dose NAC are not a clone-specific phenomenon, we tested the reproducibility of the results using another isogenic PSC pair

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