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However, results plateaued after week 10, suggesting receptor saturation or limited penetration

For example, icariin, a natural compound, has been shown to protect bone marrow mesenchymal stem cells from iron overload-induced dysfunction by modulating these pathways, thereby enhancing mitochondrial function and reducing apoptosis (91)

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By contrast, during oxidative stress, Nrf2 dissociates from Keap1, translocates to the nucleus, forms a heterodimer with small musculoaponeurotic fibrosarcoma oncogene homolog proteins and binds to ARE, thereby enhancing the transcription of antioxidant genes (6365)

Additionally, the gut microbiota-derived metabolite capsiate relieves ferroptosis-related osteoarthritis through the regulation of solute carrier family 2 member 1 and HIF-1 [99]

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