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Indeed, using different lung cancer models, we demonstrated that the DDX3X degrader J10 efficiently induces DDX3X degradation and exhibits significantly more anti-tumor effects in all in vivo models with less toxicity compared to RK-33

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Thyroid patients who also carry certain FTO (fat mass and obesity-associated) variants or MC4R (melanocortin-4 receptor) polymorphisms often experience weight loss resistance even with optimized levothyroxine replacement

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