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Levodopa, the most potent symptomatic therapy, markedly improves motor symptoms, yet it comes with considerable adverse reactions ( As early as 1982, glutathione peroxidase 4 (GPX4) was reported to inhibit the accumulation of lipid hydroperoxides, thus preventing plasma membrane damage ( - system) and shared several characteristics with ferroptosis, including reactive oxygen species (ROS) accumulation and high lipoxygenase enzymatic activity ( - system overexpression ( Figure 1 )

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Haber, (1996), Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae, Molecular and Cellular Biology , 16(5), 216473