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Take TSH (thyroid stimulating hormone): Laboratory "normal" range: 0.5 - 5.0 mIU/L Functional optimal range: 0.5 - 2.0 mIU/L Research published in the Journal of Clinical Endocrinology shows that TSH levels above 2.5 are associated with increased risk of thyroid dysfunction within 20 years

The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohns disease

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Then, query two commonly used target prediction databases, SwissTargetPrediction and Batman-TCM, to obtain 41 and 11 potential targets, respectively