They suppress appetite through hypothalamic signaling, enhance insulin sensitivity, reduce glucagon secretion, and slow gastric emptying
Alcohol use disorder (AUD) is the third-leading cause of preventable death in the United States, yet there are only three modestly effective drugs for treatment, the last one approved in 2006
doi: 10.3389/fphar.2025.1562896 121 ZhuXFowlerMJWellsQSStaffordJMGannonM
Beyond weight loss, SELECT demonstrated a 20% reduction in major cardiovascular eventsheart attacks, strokes, and cardiovascular deathin people with obesity and established heart disease
The most common gastrointestinal side effects include nausea (affecting approximately 44% of patients), vomiting (24%), dyspepsia, abdominal pain, and constipation
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