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The results of drug release experiments showed that the MNs/GLP-1RAs@NPs-WYRGRL could release approximately 92% of GLP-1RAs@NPs-WYRGRL within 2 h post-administration (Fig

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Although these data support the argument that metformin enhances both healthspan and lifespan, caution is needed because of the high concentrations of metformin, well above therapeutic levels in humans that have been used in some of the pre-clinical in vitro studies

Stay hydrated: Drink plenty of water to prevent constipation