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The real question isn't which method is "best" overall, but which one fits your specific situation, budget, and how much downtime you can handle

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A small ( n =29) randomized, crossover study using active placebo, which mimics the side effects of amitriptyline, showed the superiority of amitriptyline in relieving pain associated with DPN compared with placebo [56]

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It was gradually found that metformin can also regulate the expression of certain genes in the gut microbiota, such as BSH genes and metalloproteins genes