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There is a role to study these drugs for AE management, especially our patients on endocrine therapy

Early warning signs of hypoglycemia may be less obvious in patients with hypoglycemia unawareness which can be due to a long history of diabetes (where deficiencies in the release or response to counter regulatory hormones exist), with autonomic neuropathy, intensified diabetes control, or taking beta-blockers, guanethidine, or reserpine

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There has never been any medication that has been this effective, and the benefits are comparable to metabolic (bariatric) surgery, which remains the best evidence-based weight loss method

SEMA also reversed cerebral microcirculation effects of HFD by reducing capillary rarefaction and the interaction of leukocytes in postcapillary brain venules