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Mazloum-Ravasan, S., Madadi, E., Mohammadi, A., Mansoori, B., Amini, M., Mokhtarzadeh, A., Baradaran, B., & Darvishi, F
Withdrawal from GABAergic acting sedative-hypnotic drugs causes acute GABA-under-activity as well as glutamate over-activity which can lead to sensitization and hyper-excitability of the central nervous system, excito-neurotoxicity and increasingly profound neuroadaptions. Wikipedia Kindling (sedative-hypnotic withdrawal) Similarities Between Kindling in ME/CFS and Other Kindling Disorders ME/CFS shares many symptoms with benzodiazepine withdrawal syndrome including: agitation, chest pain, dizziness, fatigue and weakness, flu-like symptoms, irritable bowel syndrome, hot and cold flushes, orthostatic intolerance, restless leg syndrome, stiffness, tachycardia, sensitivity to touch and sound, indecision, etc
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Such efforts will accelerate the scientific development of TCM and provide a stronger, evidence-based foundation for clinical applications [671]
Nrf2- Keap1 signaling in oxidative and reductive stress
