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According to the MHRA-approved SmPC, the standard titration schedule is as follows: Weeks 14 : 0.25 mg once weekly (starting dose) Weeks 58 : 0.5 mg once weekly Weeks 912 : 1 mg once weekly Weeks 1316 : 1.7 mg once weekly Week 17 onwards : 2.4 mg once weekly (maintenance dose) At week 3, patients remain on the 0.25 mg dose