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Health alert Status: Active Date issued: 19 June 2026 Issued by: Dr Caroline McElnay, Chief Health Officer Issued to: Health professionals and the Victorian community Key messages The department has been notified of six cases of acute liver toxicity associated with an unapproved peptide product in Australia, labelled Retatrutide

Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter

This partial agonism is intrinsic to orforglipron's binding mode: as an allosteric agonist occupying a smaller binding pocket with fewer receptor contacts than peptide ligands, it stabilizes a receptor conformation that is somewhat less efficient at coupling to Gs proteins than the fully peptide-activated state

Topiramate should be considered in younger children not responding to lifestyle interventions alone with poor satiation, food cravings, binge eating, psychotropic medication-induced obesity, migraine headaches, night eating (when dosed at night), seizure disorder, idiopathic intracranial hypertension, severe non-verbal autism, or mood lability

Sirtuin activation Sirtuins (SIRT1-7) are NAD+-dependent enzymes that regulate gene expression, mitochondrial biogenesis, inflammation, and stress responses

Cichocka, M