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GLP-1 receptors (GLP-1R) are found on various immune cells, including T-cells and macrophages

For 40+ years, my work and that of others supported the view that addiction is a disorder of maladaptive dopaminergic learning

doi: 10.1038/s42255-023-00783-1 89 MoriyamaM.KoshibaT.IchinoheT

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Reframing success around health improvements rather than solely scale numbers may improve long-term adherence and reduce discouragement

Alanine scanning studies have reported that mutations of residues in the ECL3 and TM6-TM7 region also reduce GLP-1 affinity (Wootten et al., 2016