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This finding might also explain the decreased LDL susceptibility to oxidation observed in patients with homocystinuria

PLoS One 18 , e0294236 (2023)

ROS produced by NADPH oxidase activity was related to chemokine (CCL2, CXCL8, and CXCL10) production, and it was inhibited by the treatment of astrocytes with NAC or NADPH oxidase inhibitors [58]

Or the presence of extra bone at the head neck junction of the femur called a CAM lesion, the majority of situations there is a combination of both causing FAI (femoro acetabular impingement)

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This work was also supported, in part, by the Intramural Research Program of the National Institute on Aging, NIH