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11 Among these mechanisms, brain IR may play a primary role, and it is worth noting that neurologic complications may already occur with prediabetes IR

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Clinical and biomarker changes of Alzheimers disease in adults with Down syndrome: a cross-sectional study

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Conversely, peptides generally have higher specificity versus small molecules, leading to fewer off-target effects [1719, 53, 56, 58, 59]