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[143] Similarly, accumbal G9a hyperexpression results in markedly increased histone 3 lysine residue 9 dimethylation (H3K9me2) and blocks the induction of FosB-mediated neural and behavioral plasticity by chronic drug use, [sources 12] which occurs via H3K9me2-mediated repression of transcription factors for FosB and H3K9me2-mediated repression of various FosB transcriptional targets (e.g., CDK5)

El-Hage N, Wu G, Wang J, Ambati J, Knapp PE, Reed JL, et al

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Effects of DSIP on Biomarkers of Aging, Life Span, and Tumor Incidence in Female Mice

In addition, PRMT1 and UBE2m showed co-localization in HK-2 cells (Fig