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In mild cases, low levels of vitamin B12 can cause fatigue and anemia, while more serious deficiencies can lead to serious neurological and heart impairments

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Gnocchi, D., Massimi, M., Alisi, A., Incerpi, S

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As such, it makes sense that low IGF-1 levels may cause health problems like diabetes

Moderate coffee consumption increases plasma glutathione but not homocysteine in healthy subjects