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Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

Patients have reported patchy skin color (where different areas of the skin have different tones) and premature graying of hair due to the significant reduction of melanin

Additional medicinal chemistry efforts led to the discovery of benzaldehyde-based non-prodrug degraders that similarly engage C326 of FBXO22 and potently degrade NSD2

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PMID: 18 Samperio VentayolPGeiserPDi MartinoMLFlorbrantAFattingerSAWalderNet al