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10.1371/journal.pone.0196405 74

Simultaneously, the assembly and activation of the NLRP3 (nucleotide-binding domain-like receptor family pyrin domain containing-3) inflammasome complex, regulated by NF-kB, are enhanced in neurons, microglia, and astrocytes within the trigeminal ganglia, trigeminal nucleus caudalis, and cortical areas (9, 10, 39, 47)

This immune response results in a Herxheimer reaction

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People with High Environmental Exposure If you live in a city with high pollution, work outdoors in the sun, or deal with high levels of daily stress, your glutathione stores are likely being depleted faster than average