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People with treatment-resistant hypertension, especially those with co-existing diabetes, obesity, heart failure (HF), or chronic kidney disease (CKD) may particularly benefit from SGLT2-i and GLP-1RA

184 Moreover, exercise-induced exercise, such as 3-hydroxyisobutyrate, facilitates fatty acid accumulation and impairs insulin signaling in the pancreas and liver by reducing AKT phosphorylation-mediated pathways

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The tree was further decorated using the web-based tool iTOL: Interactiv Tree of Life 70 ( Data availability Gene expression datasets generated and analyzed during the current study are deposited and available at Figshare ( Primer sequences are provided in Table S1