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The depolarizing effect of GLP-1 on electrical activity was mimicked by the PKC activator PMA, occurred without activation of PKA, and persisted in the presence of PKA inhibitors, the KATP channel blocker tolbutamide, and the L-type Ca2+ channel blocker isradipine

Chemical Properties: Molecular Formula: C35H48N10O15 Molecular Weight: 848.81 g/mol Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu CAS Number: 62568-57-4 Purity: 99% (HPLC verified) BBB Permeability: High blood-brain barrier penetration DSIP Research Applications & Mechanisms Primary Research Focus Areas: 1

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These results constituted an important proof of concept for the use of long-acting GHRH analogs