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acc.org The Pharmaceutical Journal

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Berberine in high glucose-induced podocytes inhibits ROS production, promotes GSH generation, upregulates the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GPX4, and podocin, and decreases the levels of cyclooxygenase 2 and ACSL4

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If the size of the gap is significant, it may also affect tooth development