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The peptide sequence attached to the HMP linker was both side-chain deprotected and cleaved from resin by agitation with a mixture of 92.5:2.5:2.5:2.5 TFA:TIPS:EDT:H 2 O ( v / v / v / v , 5 mL) for 2 h

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When skin biopsy #3 was obtained 6 months later, the proband demonstrated a visible reduction in the hCC deposition in biopsy #3 in comparison with the original skin biopsy

Group-I mGluRs activate phospholipase C (PLC) to produce inositol 1,4,5 triphosphate (IP3) and diacylglycerol, each of which has multiple second-messenger roles (Nakanishi, 1994