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Downregulation of these metabolic enzymes in muscle even at early stages where grip strength was still intact suggests that metabolic defects in the energy producing pathways could contribute to disease progression in ALS (Tefera et al., 2016)

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Sharma HS, Hussain S, Schlager J, Ali SF, Sharma A (2010) Influence of nanoparticles on blood-brain barrier permeability and brain edema formation in rats

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Cell 137 , 10051017 (2009)