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A lower mortality in the GLP-1 RA group would expectedly lead to an underestimation of the fracture risk in that group, thereby exaggerating a protective effect of GLP-1 RAs

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By analyzing how this variant influenced different body-composition measures, the researchers could simulate the long-term effects of GLP-1 drug use without relying solely on short-duration clinical trials

Phase 2 (Jastreboff et al., NEJM 2023) reported 24.2% weight loss at 48 weeks at 12 mg