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Nobiletin prevents high-fat diet-induced dysregulation of intestinal lipid metabolism and attenuates postprandial lipemia

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10.1016/j.phrs.2019.104337 28 GennariV

Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury

Angiopoietin-2 (Ang-2) expression is elevated in brain microvascular endothelial cells (BMECs) and secreted Ang-2 can increase BBB permeability by disrupting tight junction protein structures between ZO-1 and Claudin-5 in TNBC models of brain metastasis (111)