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TB-500 is the 17-amino acid LKKTET-containing fragment of thymosin beta-4, responsible for actin cytoskeleton regulation, cell migration, and anti-inflammatory signaling

doi: 10.1038/ncb1183

The mitochondrial enzyme ALA synthase (ALAS) initiates the rate-limiting condensation of succinyl-coenzyme A and glycine to form 5-aminolevulinate (ALA) 26

However, more recently macrophages have emerged as central players in the initiation of autoimmune insulitis (immune cell infiltration of the islets) in T1D, and as the dominant immune cell population causing intra-islet inflammation in T2D (11, 12)